Specialist in active pharmaceutical ingredients of biological origin
Your expert in purification and fermentation

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Welcome to BBT Biotech GmbH

BBT Biotech GmbH is your professional and reliable partner in the development, manufacturing and international sales of biopharmaceuticals. We are located in Baesweiler near Aachen, Germany.

We are focused on our two main competences in up- and downstream processing: Fermentation and protein purification. We offer sophisticated manufacturing systems for a wide range of viable bacteria and yeasts as well as advanced protein purification and separation techniques (especially for hormones and thrombolytic drugs) including the according in-house R&D and RA competences. Furthermore, we maintain a world-class quality control department capable of performing a wide range of microbiological, biochemical, and chemical tests and analyses. This enables us to offer our customers additional laboratory services.

Manufacturing takes place under regulatory requirements GMP (Good Manufacturing Practice) resulting in the highest quality and technical standards.

Depending on individual needs, our product range offers active biopharmaceuticals as Active Pharmaceutical Ingredients (API), medical device ingredients or dosage forms.

Why you should choose BBT Biotech GmbH

Active biopharmaceuticals

Probiotics and postbiotics as API

We supply a wide range of probiotics and postbiotics as API, with batch sizes up to several kilograms, e.g.:

Multistage production facilities in Germany

Purification
Fermentation

We are inspected and audited regularly by German and international health authorities as a manufacturer of pharmaceutically active compounds.

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Development

Fermentation technology
Development of upstream processes of wild-type and recombinant microorganisms.

Key competences:
- Development and optimization of fermentation processes on a laboratory scale from 2 - 10 liter
- Development and optimization of fermentations on a pilot scale from 30 - 750 liter
- Fermentation processes of microorganisms on a scale of up to 18,000 liter
- Media development: media design and nutrient feeding strategies
- Fermentation strategies: batch, fed-batch, and continuous processes
- Cell growth and product formation: kinetics, yields and process parameters
- Analytical measurements mostly performed in-house
- Lyophilization
Protein purification
Development of downstream processes to isolate proteins of natural origins as well as recombinant proteins.

Key competences:
- Development and optimization of medium scale chromatographic purification steps for batch sizes from a few gram to several kilograms of purified final product
- Development and optimization of ultrafiltration processes in medium scale from 500 ml up to 100 l
- Development and optimization of lyophilization processes
- Analytical measurements mostly performed in-house

GMP (Good Manufacturing Practices)

Manufacturing takes place under regulatory requirements (GMP; Good Manufacturing Practice) resulting in the highest quality and technical standards. For proteins and microorganisms, we own the manufacturing authorization according to the AMG (Arzneimittelgesetz; german drug law). We further hold a manufacturing authorization for biological hormones according to the TAMG (Tierarzneimittelgesetz; german veterinary drug law).

We are regularly inspected by the German health authorities and other bodies supervising the manufacturing of biopharmaceutical active ingredients. Each of our products undergoes rigorous testing according to GMP and international pharmacopoeia standards to confirm their identity, purity, and activity to the pharmaceutical grade. This and the validated production procedures ensures highest quality standards.

This makes BBT one of the biotechnology companies in Germany that can guarantee GMP-compliant pharmaceutical production.